Title of Project:
Replicons and Infectious Copies In the Study of Animal Pathogens
Members :
- Graduate Institute of Animal Vaccine Technology
- Professor Chun-Yen Chu
- Graduate Institute of Animal Vaccine Technology
- Postdoctoral Researcher Hsing-Chieh Wu
Invited International Teachers and Students :
- University of St.Andrews, Biomedical Sciences Research Complex, School of Biology
- Professor Martin Ryan
- University of St.Andrews, Biomedical Sciences Research Complex, School of Biology
- Postdoctoral Researcher Fiona Tulloch
- University of St.Andrews, Biomedical Sciences Research Complex, School of Biology
- Postdoctoral Researcher Garry Luke
Cooperative Topics and Research Content:
This purpose of the application is to link laboratories in the Taiwan with UK apply replicons and infectious copies technology. Develop a virus replicon system by replacing sequences encoding the viral proteins of the infectious cDNA copy with reporter proteins. Characterization in tissue-cultures cells, latterly animals, will allow us to create a sequence such that the right level of attenuation can be achieved. This procedure potentially provides the means to produce a new generation of safer live attenuated vaccines.
Description of Industrial Needs and Research Result Applications:
This program of work progresses from basic academic research via further basic research into the immune responses of animal model systems – but directly leads to the application of our science for the development of animal vaccines. The national capacity for the development and production of vaccines will be enhanced by this project.
Research and Development Performance:
We have applied for the international partnering project from Ministry of Science and Technology to extend our collaboration. Moreover, the publications (conference presentations / papers / reports) are under process.